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Manager / Senior Manager (Clinical Operations), CADENCE

Overview

 

The Consortium for Clinical Research and Innovation, Singapore (CRIS) brings together seven national R&D, clinical translation and service programmes to advance clinical research and innovation for Singapore, and establish important capabilities for a future-ready healthcare system.

 

The Business Entities under CRIS include:

  • Singapore Clinical Research Institute (SCRI)
  • National Health Innovation Centre (NHIC)
  • Advanced Cell Therapy and Research Institute, Singapore (ACTRIS)
  • Precision Health Research, Singapore (PRECISE)
  • Singapore Translational Cancer Consortium (STCC)
  • Cardiovascular Disease National Collaborative Enterprise (CADENCE)
  • Singapore Medical Foundation AI model (SIMFONI)

 

Together, CRIS makes a positive difference to Singapore patients and researchers by ensuring that these clinical research platforms and programmes are at the cutting edge of capability development and innovation. If you are as passionate as we are in clinical trials and research, we want you!

 

CADENCE

 

The Cardiovascular Disease National Collaborative Enterprise (CADENCE) is a national program for Cardiovascular Research that aims to strengthen the overall impact of cardiovascular research and translation in Singapore through: (1) synergising efforts across Singapore through the establishment of Joint Platforms to improve patient outcomes and establish Singapore as a global leader in cardiovascular disease (CVD) research; (2) overcoming common barriers to research at the systems level; (3) driving commercialisation efforts; and (4) demonstrating the power of these synergies through a series of practice-changing Use Cases.

 

CADENCE will be housed as a business unit within the Consortium for Clinical Research and Innovation Singapore (CRIS), a wholly-owned subsidiary of the Ministry of Health Holdings (MOHH) Pte Ltd and anchored by the CVD research programmes and commercialization platforms of partner institutions (MOHT, NHCS & NHRIS, NUHCS & CVRI, NHG Heart Institute, KTPH, A*STAR, NUS, Duke-NUS, LKC).

 

What you will be working on

 

The Clinical Operations Manager/Senior Manager will assist and/or oversight the strategic and operational execution of cardiovascular clinical trials within the CADENCE National Clinical Translational Programme. This role combines hands-on project management expertise with strategic network leadership to establish Singapore as the premier Asian hub for cardiovascular research excellence. The ideal candidate should be seasoned clinical trials expert with a proven ability to navigate complex, multi-institutional environments.

 

Responsibilities:

 

Strategic Leadership & Network Management

 

  • Serve as liaison for the National CV Clinical Trials Network, coordinating across multiple sites, industry partners, and international collaborators
  • Drive expansion of local and regional CV trial networks to enhance Singapore's competitive positioning
  • Lead implementation of Investigator-Sponsored Trials (ISTs) and Investigator-Initiated Trials (IITs) from conception through closeout
  • Develop strategic partnerships and resolve contractual barriers to accelerate trial setup and execution

 

Operational Excellence

 

  • Oversee end-to-end management of multi-site cardiovascular clinical trials (Phase I-IV) ensuring delivery on time and within budget
  • Establish and implement SOPs, work instructions, and best practices to harmonise multi-site trial operations
  • Ensure compliance with ICH-GCP, FDA, EMA, and HSA regulatory requirements as applicable across all managed trials
  • Lead project discussions independently and manage stakeholder expectations effectively

 

Team Leadership & Development

 

  • Provide mentorship and guidance to clinical operations staff, fostering excellence and innovation
  • Ensure project team members are qualified and equipped with required skillsets
  • Collaborate with delegated personnel on contracts and partnerships
  • Build and maintain strong relationships across diverse stakeholder groups

 

Quality & Financial Management

 

  • Contribute to and implement robust research quality frameworks within CADENCE
  • Oversee proper budgeting and accounting of research funds, ensuring compliance with financial policies
  • Track KPIs, monitor progress, and provide regular updates to senior leadership
  • Ensure optimal resource allocation and utilisation across multiple concurrent projects

 

Requirements:

 

  • Bachelor’s/Master’s degree in Life Sciences, Nursing, or a related field
  • Over 8 years of experience in clinical operations, with expertise in multi-site trials (drug/device) and early-phase studies (Phase I-II)
  • Proven track record in IST/IIT management and regulatory compliance
  • Expert knowledge of ICH-GCP, HSA/MOH regulations, and international regulatory frameworks
  • Industry/pharmaceutical experience will be considered an advantage
  • Strong project management (PMP/Prince2 certification preferred) and negotiation skills
  • Meticulous attention to detail with ability to thrive in fast-paced environments
  • Ability to drive multi-institutional collaborations and resolve contractual barriers
  • Ability to work flexibly including international time zones when required

 

 

What you need to know

 

Successful candidate will be offered a 2-year renewable contract. We regret that only shortlisted candidates will be contacted. 

 

For more information about CRIS and the Business Entities, visit our websites below:

 

CRIS – https://www.cris.sg

SCRI – https://www.scri.edu.sg

NHIC – https://www.nhic.sg

ACTRIS – https://www.actris.sg

PRECISE – https://www.npm.sg

STCC – https://www.stcc.sg

CADENCE – https://www.cris.sg/our-programmes/cadence/

 

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